Many adverse effects of licorice poisoning can be seen and most are attributed to the mineralocorticoid effects of GZA. Depending on the dose and intake of licorice, serious problems and even hospitalization can arise. People with previously existing heart or kidney problems may be more susceptible to GZA and licorice poisoning.  It is important to monitor the amount of licorice consumed in order to prevent toxicity. It is difficult to determine a safe level, due to many varying factors from person to person. In the most sensitive individuals, daily intake of about 100 mg GZA can cause problems.  This is equivalent to 50 g licorice sweets. However, in most people, they can consume up to 400 mg before experiencing symptoms, which would be about 200 g licorice sweets. A rule of thumb says a normal healthy person can consume 10 mg GZA a day. 
Calcitonin gene-related peptide is a neuropeptide thought to be central to migraine pathogenesis. Intravenous infusion of a calcitonin gene-related peptide antagonist showed promising results in one small study. 35 Transcranial magnetic stimulation, a modality where a magnetic field is generated on the scalp to create currents in the adjacent cortex, seems promising. A controlled trial of 200 patients who had migraine with aura showed that this therapy is superior to sham in two-hour pain relief and sustained responses over 24 to 48 hours. 36 Further research is needed to evaluate its role in treating migraine without aura and in migraine prophylaxis.