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While her reassurances comforted me, they also seemed to contradict my psychiatrist’s advice that I remain on long-term drug treatment to avoid the high risk of recurrences – and, perhaps, to repair some of the cell damage that my previous depression had caused. Whatever neural and psychological processes might be at play, the statistics I’d seen seemed convincing. When the psychiatrist John Geddes at the University of Oxford and colleagues analysed 31 different randomised drug trials, they found that staying on antidepressant drugs after an episode of illness reduced the chances of relapse by 70 per cent. Depending on the trial, this effect remained constant for anywhere from 12 to 36 months after the beginning of treatment. (Put another way, 41 per cent of trial participants on placebo relapsed after their initial episode, whereas only 18 per cent on antidepressants did.)